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Imagine being trapped in a freezing body from head to toe, losing the ability to move, speak and even breathe. ALS, a mysterious condition that causes these symptoms, has long puzzled researchers. CUHK and University of Oxford researchers have discovered our bodies work like an intricate symphony orchestrated by our genetic instructions. A transcription factor called Yin Yang 1 (YY1) is playing the wrong notes, potentially leading to ALS.