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The Discovery of an Oncogene in Gastric Cancer Overturns Previous Reports

Cancer is a group of diseases that we are taking kinds of strategies to overcome at the moment. Our bodies are made up of countless cells, and cancer cells are the result of mutations of normal ones. Although its causes are not yet fully understood, studying the mechanisms of cancer cell proliferation allows us to understand cancer better and create new treatments. A team from CU Medicine has just identified a novel oncogene in gastric cancer, giving rise to the development of a new anti-cancer therapy……

COVID mRNA Booster Key to Protecting High-risk Populations

CU Medicine has conducted what is, to date, the largest sample (about 100 million subjects), worldwide study of 24 combinations of COVID-19 vaccines covering seven vaccine types. It shows that, whilst three doses of an mRNA vaccine greatly reduce COVID-19 infection risks in immunocompromised and elderly patients compared to only two doses of vaccines of any kind, an mRNA booster to two doses of any other vaccine protects them against non-severe COVID-19 infections. Very importantly, say the findings, a third dose of mRNA vaccine is necessary to protect against Omicron infection……

CUHK Scholars and Students Given Awards for Innovative Research

Professor Mei-Po KWAN from CUHK’s Department of Geography and Resource Management has been awarded the James R. Anderson Medal of Honor in Applied Geography, the highest honour in the field, for her multidisciplinary contributions to applied geography; while Professor YU Jun from the Faculty of Medicine has been awarded the Guanghua Engineering Science and Technology Award by the Chinese Academy of Engineering in recognition of her distinguished achievements in gastrointestinal cancer studies……

Gut Feeling about Handling Long COVID

The Microbiota I-Centre of CUHK has identified distinct gut microbiome profiles that can characterise “long COVID”. This is the world’s first study to demonstrate gut microbiota as a key determinant of long COVID. These distinct gut microbial signatures can be used as a diagnostic tool and to guide therapy……

New Light on Causes of Severe Inflammation in COVID Patients’ Blood Vessels

A new pathway has been found whereby SARS-CoV-2 infects the endothelium cells – the innermost layer of the blood vessels, causing hyper inflammation, blood clotting and thrombosis in severe COVID-19 patients. In a collaborative research, a CU Medicine team has discovered that the virus induces inflammation by activating a unique cell surface receptor called (TLR) 4, without entering the host cell……

Gold Nanoparticle in Long Awaited Strike for Psoriasis Sufferers

Gold is anti-inflammatory and has applications in the fields of jewelry, aviation, chemistry, and electronic circuit boards. Now researchers from CUHK Engineering have struck gold for psoriasis sufferers by developing a self-therapeutic gold nanoparticle that does not contain steroids and vitamin D analogs but has a similar effect, as proven in mice models. It was demonstrated that the gold nanoparticle could enter skin epidermal cells without causing hair loss and skin wrinkling……

Strengthened Response to COVID Vaccines Could Come from the Gut

Sinovac and BioNTech work more effectively in people who have an abundance amount of a particular bacterium called Bifidobacterium adolescentis in their gut. In most of us, this reduces with age, modern diet, stress, and the use of antibiotics, and a joint CUHK-HKU study has found that those who lack it have a lower antibody response to the vaccines. This implies that modulating the gut has potential to power up the impact of COVID vaccines……

A Predictive Platform to Combat Infertility

Anticipating a newborn brings joy to parents but delays in marriages and childbirth planning make it harder to conceive successfully. Selecting a high developmental potential embryo is still the key to pregnancy even though assisted reproductive technology like conventional IVF has been advancing with time. CUHK researchers have recently developed a new predictive platform which helps doctor to select an appropriate embryo and devise transfer schemes to increase the rate of success……

No More Probes! World-First Sensitive Faecal Test for Colon Cancer and Polyps Detection

A low sensitivity faecal test is used to screen for colorectal cancer. Its cause, polyps can only be detected by a probing colonoscopy. Now a CUHK Medicine team has devised a first ever, highly sensitive, non-invasive “bacterial gene markers” test on faeces. It is 94% sensitive to the cancer, and over 90% sensitive to recurring polyps - which the present test can’t detect at all……

FEATURE

Once Fighting Hepatitis, Now Re-enlisted to Confront COVID-19.

Simeprevir was a successful drug retired from the fight against the hepatitis C virus when new drugs and advanced treatment came into the field in recent years. An international research team led by CUHK and HKU seeking an effective drug molecule against COVID-19 has re-enlisted simeprevir as a potent treatment to suppress the replication of SARS-CoV-2……